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Protecting groups
BASF products that pave your way
Benzophenone imine is a recent addition to BASF’s portfolio, which now offers another new protecting group of great interest. Benzophenone imine can also be used as a building block, for example for introducing the amine function into a molecule.
Protecting groups are useful in many complex syntheses of active pharmaceutical ingredients (APIs) when functional groups of a molecule need to be protected from an undesirable reaction. Due to its properties benzophenone imine is eminently suitable for a number of synthesis routes.
The reaction scheme below illustrates the use of benzophenone imine as protecting group. First, glycine methyl ester is reacted with benzophenone imine. This is followed by alkylation, for example with an alkylhalide. After removal of the protecting group, an α-substituted glycine ester derivative is obtained:
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Since benzophenone imine is highly reactive, it should be used without delay. On request BASF will therefore guarantee its availability in the quantities required at short notice – in volumes ranging from kilogram- to ton-scale.
Along with benzophenone imine BASF offers a comprehensive portfolio of other protecting groups for a broad range of applications. Typical examples include pivaloyl chloride, benzylchloroformate and dihydropyran to protect alcohols or amines.
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